Interesting article in Time Magazine about a woman named Lonni Sue Johnson who was a very successful artist, violinist and pilot until she suffered an attack of encephalitis in 2007 at the age of 57. Studying patients like Johnson, scientists are learning about the relationship between the physical brain and experiences and even the nature of 'self'.
With the help of the hardware and Johnson's willingness to sit still for so much study, science may be able to answer one other, more abstract question: What is it like to have lost so many memories about your life and the world? If who you are is an amalgamation, at least in part, of the things you've experienced--the people you've loved, the places you've lived, the tragedies you've endured--are you actually you at all when those things are wiped away? The self is ineffable, but it's also material, the product of neurochemicals sparking their way through living tissue. How we draw the line between those two dimensions--the biological and the experiential, the brain and the far less knowable mind--has kept philosophers awake for millennia.